Endodontics is the branch and specialty of dentistry concerned with the morphology, physiology, and pathology of the dental pulp and periradicular tissues. Its study and practice encompass basic clinical sciences, including biology of the normal pulp, etiology, diagnosis, treatment of diseases and injuries of the pulp and associated periradicular tissues.


The NDSE will test a candidate's knowledge of endodontic principles at the specialty level in Canada.


Canadian endodontists are required to have broad knowledge and skills in eleven domains. The blueprint below presents the domains and the approximate percentage of questions covered by each domain. 

Endodontics Blueprint

Approximate % of questions

Biomedical Sciences (Includes anatomy, physiology, oral histology, oral pathology, oral histopathology, oral microbiology, immunology, biomaterials)


Non-surgical root canal therapy


Surgical root canal therapy


Diagnosis, treatment planning, and patient management








Treatment of medically compromised patient




Research methods


Miscellaneous topics (includes prosthodontics, periodontics, orthodontics, ethics, asepsis & sterilization, implantology) 





The examination will consist of two three-hour parts. The format consists of a mix of stand-alone short- and long-answer questions that assess knowledge and application, and case-based questions that assess diagnostic and clinical decision-making ability.

References and Resources

References for Knowledge of the Literature Questions

American Association of Endodontists. (2013). The Recommended Guidelines of the American Association of Endodontists for The Treatment of Traumatic Dental Injuries. Retrieved from https://www.aae.org/specialty/wp-content/uploads/sites/2/2019/02/19_TraumaGuidelines.pdf

Antman, E. M., Bennett, J. S., Daugherty, A., Furberg, C., Roberts, H., & Taubert, K. A. (2007). Use of nonsteroidal antiinflammatory drugs. Circulation, 115(12), 1634–1642.

Beach, C., Calhoun, J., Bramwell, J., Hutter, J. & Miller, G. (1996). Clinical evaluation of bacterial leakage of endodontic temporary filling materials. Journal of Endodontics, 22(9), 459–462.

Byström , A., & Sundqvist, G. (1983). Bacteriologic evaluation of the effect of 0.5 percent sodium hypochlorite in endodontic therapy. Oral Surg Oral Med Oral Pathol , 55(3), 307–312.

Canadian Pharmacists Association. (2019). CPS 2019 - Compendium of pharmaceuticals and specialties. Ottawa, Canada: Author.

Cullen, J. K. T., Wealleans, J. A., Kirkpatrick, T. C., & Yaccino, J. M. (2015). The Effect of 8.25% Sodium Hypochlorite on Dental Pulp Dissolution and Dentin Flexural Strength and Modulus. Journal of Endodontics, 41(6), 920–924. https://doi.org/10.1016/j.joen.2015.01.028

Figueiredo, F. E. D., Martins-Filho, P. R. S., & Faria-e-Silva, A. L. (2015). Do metal post–retained restorations result in more root fractures than fiber post–retained restorations? A systematic review and meta-analysis. Journal of Endodontics, 41(3), 309–316.

Fletcher, R., Fletcher S.W. (2012). Clinical epidemiology: the essentials. (5th ed.) Philadelphia: Lippincott Williams & Wilkins.

Giglio, J., Lanni, S. M., Laskin, D. M., & Giglio, N. W. (2009). Oral health care for the pregnant patient. Journal of the Canadian Dental Association, 75(1), 43–48.

Gilheany, P. A., Figdor, D., & Tyas, M. J. (1994). Apical dentin permeability and microleakage associated with root end resection and retrograde filling. Journal of Endodontics, 20(1), 22–26.

Haapasalo, H. K., Siren, E. K., Waltimo, T. M. T., Orstavik, D., & Haapasalo, M. P. P. (2000). Inactivation of local root canal medicaments by dentine: an in vitro study. International Endodontic Journal, 33(2),126–131.

Harrison, J. W., & Jurosky, K. A. (1991). Wound healing in the tissues of the periodontium following periradicular surgery. I. The incisional wound. Journal of Endodontics, 17(9), 425–435.

Lockhart, P. B., et al. (2012). Periodontal disease and atherosclerotic vascular disease: Does the evidence support an independent association? Circulation, 125(20), 2520–2544.

Lockhart, P. B., Tampi, M. P., Abt, E., Aminoshariae, A., Durkin, M. J., Fouad, A. F., & Carrasco-Labra, A. (2019). Evidence-based clinical practice guideline on antibiotic use for the urgent management of pulpal- and periapical-related dental pain and intraoral swelling. The Journal of the American Dental Association, 150(11), 906-921.e12.

Nair, P. N. R. (1998). New perspectives on radicular cysts: Do they heal? International Endodontic Journal, 31(3),155–160.

Nair, P. N. R., Sjogren, U., & Sundqvist, G. (1998). Cholesterol crystals as an etiological factor in non-resolving chronic inflammation, an experimental study in guinea pigs. European Journal of Oral Sciences, 106(2p1), 644–650.

Nixdorf, D. R., Moana-Filho, E. J., Law, A. S., McGuire, L. A., Hodges, J. S., & John, M. T. (2010). Frequency of nonodontogenic pain after endodontic therapy: A systematic review and meta-analysis. Journal of Endodontics, 36(9),1494–1498.

Read, J. K., McClanahan, S. B., Khan, A. A., Lunos, S., & Bowles, W. R. (2014). Effect of Ibuprofen on masking endodontic diagnosis. Journal of Endodontics, 40(8),1058–1062.

Ricucci, D., & Siqueira Jr., J. F. (2010). Fate of the tissue in lateral canals and apical ramifications in response to pathologic conditions and treatment procedures. Journal of Endodontics, 36(1), 1–15.

Sjögren, U., Hägglund, B., Sundqvist, G., & Wing, K. (1990). Factors affecting the long-term results of endodontic treatment. Journal of Endodontics, 16(10), 498–504.

Spili, P., Parashos, P., & Messer, H. H. (2005). The Impact of instrument fracture on outcome of endodontic treatment. Journal of Endodontics, 31(12), 845–850.

Tsesis, I., Faivishevsky, V., Fuss, Z., & Zukerman, O. (2008). Flare-ups after endodontic treatment: A meta-analysis of literature. Journal of Endodontics, 34(10), 1177–1181.

Uraba, S., Ebihara, A., Komatsu, K., Ohbayashi, N., & Okiji, T. (2016). Ability of cone-beam computed tomography to detect periapical lesions that were not detected by periapical radiography: A retrospective assessment according to tooth group. Journal of Endodontics, 42(8), 1186–1190.

Wang, X., Thibodeau, B., Trope, M., Lin, L. M., & Huang, G. T.-J. (2010). Histologic Characterization of Regenerated Tissues in Canal Space after the Revitalization/Revascularization procedure of Immature dog teeth with apical periodontitis. Journal of Endodontics, 36(1), 56–63.

Other References

Dowd, F. J., Johnson, B., & Mariotti, A. (2016). Pharmacology and therapeutics for dentistry (7th ed.). Maryland Heights, Missouri: Mosby.

Duncan, H. F., & Cooper, P. R. (2018). Clinical approaches in endodontic regeneration: Current and emerging therapeutic perspectives (1st ed.). New York: Springer Publishing.

Gutmann, J. L., & Lovdahl, P. E. (2010). Problem solving in endodontics: Prevention, identification and management (5th ed.). Maryland Heights, Missouri: Mosby.

Hargreaves, K. M., & Berman, L. (2016). Cohen’s pathways of the pulp (11th ed.). St. Louis: Elsevier.

Hargreaves, K. M., & Goodis, H. E. (2012). Seltzer and Bender’s dental pulp (2nd ed.). Boston: Quintessence Publishing.

Laskin, D. M., & Carlson, E. R. (2018). Clinician’s handbook of oral and maxillofacial surgery (2nd ed.). Boston: Quintessence Publishing.

Liebgott, B. (2017). The anatomical basis of dentistry (4th ed.). Maryland Heights, Missouri: Mosby.

Little, J., Falace, D., Miller, C. S., & Rhodus, N. L. (2018). Dental management of the medically compromised patient (9th ed.). Maryland Heights, Missouri: Mosby.

Malamed, S. F. (2019). Handbook of local anesthesia (7th ed.). Maryland Heights, Missouri: Mosby.

Nanci, A., & Ten Cate, A. R. (2018). Ten Cate's oral histology: Development, structure, and function (9th ed.). St. Louis: Elsevier.

Ritter, A. V. (2018). Sturdevant's art and science of operative dentistry (7th ed.). St. Louis: Elsevier